Use of teduglutide in adults with short bowel syndrome-associated intestinal failure

Nutr Clin Pract .2023 Jun 9. doi: 10.1002/ncp.11015. Online ahead of print. Loris Pironi, Johane P Allard, Francisca Joly, Parnia Geransar, Elisabeth Genestin, Ulrich-Frank PapePMID: 37294295 DOI: 10.1002/ncp.11015 Abstract Short bowel syndrome (SBS) is a rare gastrointestinal disorder associated with intestinal failure (SBS-IF) and poor health-related outcomes. Patients with SBS-IF are unable to absorb sufficient nutrients or fluids to maintain significantly metabolic […]

Use of teduglutide in adults with short bowel syndrome-associated intestinal failure Read More »

Orally compensated short bowel patients are thin, potentially malnourished but rarely sarcopenic

Clin Nutr. 2023 Aug;42(8):1480-1490. doi: 10.1016/j.clnu.2023.05.018. Epub 2023 May 25. Karen Bannert, Cathleen Karbe, Robert H Förster, Lea F Sautter, Fatuma Meyer, Luzia Valentini, Mats L Wiese, Luise Ehlers, Peggy Berlin, Robert Jaster, Ali A Aghdassi, Markus M Lerch, Georg LamprechtPMID: 37311685 DOI: 10.1016/j.clnu.2023.05.018 Abstract Background & aims:  In short bowel syndrome, insufficient absorptive capacity of the remnant bowel may lead to metabolic and nutritional consequences including electrolyte disturbances, severe

Orally compensated short bowel patients are thin, potentially malnourished but rarely sarcopenic Read More »

Quality of Life in Teduglutide-Treated Patients with Short Bowel Syndrome Intestinal Failure-A Nested Matched Pair Real-World Study

Nutrients.2023 Apr 18;15(8):1949. doi: 10.3390/nu15081949. Elisabeth Blüthner, Ulrich-Frank Pape, Frank Tacke, Sophie Greif PMID: 37111167 DOI: 10.3390/nu15081949 Abstract Background: Quality of life (QoL) data of chronic intestinal failure (cIF) patients treated with the GLP-2 analogue teduglutide are scarce. This study aims to analyze QoL changes over time in teduglutide-treated patients and compare the results to a matched non-treated cIF control

Quality of Life in Teduglutide-Treated Patients with Short Bowel Syndrome Intestinal Failure-A Nested Matched Pair Real-World Study Read More »

Long-term results of teduglutide treatment for chronic intestinal failure – Insights from a national, multi-centric patient home-care service program

ORIGINAL ARTICLE| VOLUME 51, P222-230, OCTOBER 2022 Sophie Greif, Sebastian Maasberg, Jan Wehkamp, Elisabeth Blüthner, Frank Tacke, Ulrich-Frank PapeDOI: https://doi.org/10.1016/j.clnesp.2022.08.027 Abstract Background & aims: Teduglutide is a Glucagon-like peptide-2 (GLP-2) agonist indicated for the treatment of patients with parenteral support (PS) dependent short bowel syndrome (SBS) with chronic intestinal failure (cIF). Its application is accompanied by a structured

Long-term results of teduglutide treatment for chronic intestinal failure – Insights from a national, multi-centric patient home-care service program Read More »

Severe acute respiratory syndrome coronavirus 2 antibody prevalence in adult patients with short bowel syndrome—A German multicenter cross‐sectional study

Clin Nutr. 2015 Dec;34(6):1128-32. doi: 10.1016/j.clnu.2014.11.009. Epub 2014 Nov 20. The continued rise of paediatric home parenteral nutrition use: Implications for service and the improvement of longitudinal data collection Elisabeth Blüthner, Ulrich‐Frank Pape,  Irina Blumenstein,  Jeanette Wichmann, Frank Tacke, and Simon Moosburner,PMID: 35616296 DOI: 10.1002/jpen.2410 Abstract Background: Not all patients suffer from a severe course of severe acute respiratory

Severe acute respiratory syndrome coronavirus 2 antibody prevalence in adult patients with short bowel syndrome—A German multicenter cross‐sectional study Read More »

Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel

JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):1107-1118. doi: 10.1002/jpen.2286. Epub 2021 Nov 18. Johannes Reiner, Peggy Berlin, Jascha Held, Johanna Thiery, Jolanta Skarbaliene, Jonathan Griffin, Wayne Russell, Per-Olof Eriksson, Mark Berner-Hansen, Luise Ehlers, Brigitte Vollmar, Robert Jaster, Maria Witte, Georg LamprechtPMID: 34705281 DOI: 10.1002/jpen.2286 Abstract Background: Extensive intestinal resection may lead to short bowel (SB) syndrome, resulting in intestinal insufficiency or intestinal failure (IF). Intestinal insufficiency and IF involve deficiency of the

Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel Read More »

Chronic intestinal failure

Chirurg. 2022 Feb;93(2):205-214. doi: 10.1007/s00104-021-01423-8. Epub 2021 Jul 15. Jens G Brockmann, Anna Hüsing-Kabar, Katharina Bohlen, Caro Lin Höckelmann, Andreas PascherPMID: 34264370 DOI: 10.1007/s00104-021-01423-8 Abstract The term intestinal failure (IF) is understood as the transient or irreversible loss of the resorptive capacity of the bowels. This includes a multitude of diseases, some of which have anatomical causes and others functional causes. The

Chronic intestinal failure Read More »

Chronic intestinal failure and short bowel syndrome in Crohn’s disease

World J Gastroenterol. 2021 Jun 28;27(24):3440-3465. doi: 10.3748/wjg.v27.i24.3440. Aysegül Aksan, Karima Farrag, Irina Blumenstein, Oliver Schröder, Axel U Dignass, Jürgen SteinPMID: 34239262 DOI: 10.3748/wjg.v27.i24.3440 Abstract Chronic intestinal failure (CIF) is a rare but feared complication of Crohn’s disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide

Chronic intestinal failure and short bowel syndrome in Crohn’s disease Read More »

SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase

Hum Mol Genet . 2019 Mar 1;28(5):828-841. doi: 10.1093/hmg/ddy394. Andrew R Barclay, Paul Henderson, Henry Gowen, John Puntis; BIFS collaborators Lasse Holt-Danborg, Julia Vodopiutz, Annika W Nonboe, Jan De Laffolie, Signe Skovbjerg, Victorien M Wolters, Thomas Müller, Benjamin Hetzer, Alexander Querfurt, Klaus-Peter Zimmer, Jan K Jensen, Andreas Entenmann, Peter Heinz-Erian, Lotte K Vogel, Andreas R JaneckePMID: 30445423 DOI: 10.1093/hmg/ddy394 Abstract The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi-allelic mutations

SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase Read More »

Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency

Dig Dis Sci. 2020 Dec;65(12):3521-3537. doi: 10.1007/s10620-020-06140-6. Epub 2020 Feb 19. Johannes Reiner, Peggy Berlin, Jakob Wobar, Holger Schäffler, Karen Bannert, Manuela Bastian, Brigitte Vollmar, Robert Jaster, Georg Lamprecht, Maria WittePMID: 32072437 DOI: 10.1007/s10620-020-06140-6 Abstract Background: In short bowel syndrome, epithelial surface loss results in impaired nutrient absorption and may lead to intestinal insufficiency or intestinal failure. Nucleotide oligomerization domain 2 (Nod2) dysfunction predisposes to the development of

Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency Read More »

Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation.

Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation. FASEB J. 2020 Mar;34(3):3983-3995. doi: 10.1096/fj.201901758RR. Epub 2020 Jan 19. PMID: 31957074. de Laffolie J, Sheridan D, Reinshagen K, Wessel L, Zimmermann C, Stricker S, Lerch MM, Weigel M, Hain T, Domann E, Rudloff S, Nichols

Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation. Read More »

Malnutrition and Intestinal Failure

Special Collection:  Karger e-Journal Complete Collection 2019 ,  Karger Biomedical Online Collection 2019 ,  Karger e-Journal Backfile Collection 2019 , Focus Article Georg Lamprecht, Irina BlumensteinVisc Med (2019) 35 (5): 281. DOI: 10.1159/000503610 Abstract Adequate nutrition is a fundamental physiological function comparable to electrolyte homeostasis and coagulation but with a different time frame both in its deterioration and its (re)compensation. Nutritional status may

Malnutrition and Intestinal Failure Read More »

Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography

Nutrition. 2019 Jul-Aug;63-64:134-140. doi: 10.1016/j.nut.2019.02.001. Epub 2019 Feb 13. Viola Knop, Sophie-Charlott Neuberger, Sabine Marienfeld, Jörg Bojunga, Eva Herrmann, Thierry Poynard, Stefan Zeuzem, Irina Blumenstein, Mireen Friedrich-RustPMID: 30959382 DOI: 10.1016/j.nut.2019.02.001 Abstract Objective: Patients with short bowel syndrome (SBS) receiving long-term parenteral nutrition (PN) are at risk for intestinal failure-associated liver disease (IFALD). The aim of the present study was to evaluate dynamic changes of liver fibrosis and

Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography Read More »

Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition

Clin Nutr. 2020 Feb;39(2):540-547. doi: 10.1016/j.clnu.2019.02.039. Epub 2019 Mar 5. Elisabeth Blüthner, Jan Bednarsch, Ulrich-Frank Pape, Mirjam Karber, Sebastian Maasberg, Undine A Gerlach, Andreas Pascher, Bertram Wiedenmann, Johann Pratschke, Martin Stockmann PMID: 30885502 PMID: 30885502 DOI: 10.1016/j.clnu.2019.02.039 Abstract Background & aims: Intestinal failure associated liver disease (IFALD) is one of the leading complications and causes of deaths in adult patients receiving home parenteral nutrition for chronic intestinal failure (CIF).

Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition Read More »

Intestinale Rehabilitation bei Kurzdarmsyndrom und chronischem Darmversagen

Dtsch Med Wochenschr 2019; 144(15): 1061-1066 Ulrich-Frank Pape, Sebastian MaasbergDOI: 10.1055/a-0651-4481 Abstract Patients with severely orally decompensated malsaborption due to surgical rescetion suffer from short bowel syndrome (SBS). The resultant decrease in intestinal surface area after rescetion of parts of the intestines leads to chronic functional intestinal insufficiency or even complete failure (cIF) which requires parenteral

Intestinale Rehabilitation bei Kurzdarmsyndrom und chronischem Darmversagen Read More »

Starch Tolerance and the Short Bowel

Starch Tolerance and the Short Bowel. J Pediatr Gastroenterol Nutr. 2018 Jun;66 Suppl 3:S68-S71. Jan de Laffolie, Hassan Y Naim, Silvia Rudloff, Klaus-Peter ZimmerPMID: 29762383 DOI: 10.1097/MPG.0000000000001962 Abstract Short bowel syndrome with intestinal failure is a rare disease with a massive impairment in quality of life, requiring a multidisciplinary team approach to medical, surgical, and nutritional therapy. Current pharmacological and

Starch Tolerance and the Short Bowel Read More »

Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure.

Joly F, Baxter J, Staun M, et al.: Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure. Clin Nutr 2017; 37: 1415–22.PMID: 28701261 DOI: 10.1016/j.clnu.2017.06.016 Abstract Background & aim: Home parenteral nutrition (HPN) is the primary treatment for chronic intestinal failure (IF). Intestinal transplantation (ITx) is indicated when

Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure. Read More »

Endocytosis in enterocytes

2016 May;166(7-8):205-10. doi: 10.1007/s10354-016-0448-z. Epub 2016 Mar 18.Endocytosis in enterocytes Klaus-Peter Zimmer, Jan de Laffolie, Maria Vittoria Barone, Hassan Y NaimAffiliationsPMID: 26993488 DOI: 10.1007/s10354-016-0448-z Abstract Endocytosis is a fundamental cell biological process, which carries out essential functions in a polarized epithelial cell such as enterocytes provided with a huge surface area of the brush border membrane. Major tasks

Endocytosis in enterocytes Read More »

Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral Center

JPEN J Parenter Enteral Nutr. 2017 Sep;41(7):1178-1187. doi: 10.1177/0148607116655449. Epub 2016 Jun 20.Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral CenterChristopher Filtenborg Brandt, Mark Hvistendahl, Rahim M Naimi, Siri Tribler, Michael Staun, Per Brøbech, Palle Bekker JeppesenPMID: 27323776 DOI: 10.1177/0148607116655449 Abstract Background/aims: In Denmark,

Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral Center Read More »

The continued rise of paediatric home parenteral nutrition use: Implications for service and the improvement of longitudinal data collection

Clin Nutr. 2015 Dec;34(6):1128-32. doi: 10.1016/j.clnu.2014.11.009. Epub 2014 Nov 20.The continued rise of paediatric home parenteral nutrition use: Implications for service and the improvement of longitudinal data collection Andrew R Barclay, Paul Henderson, Henry Gowen, John Puntis; BIFS collaboratorsPMID: 25476040 DOI: 10.1016/j.clnu.2014.11.009 Abstract Background & aims: Robust data from the United Kingdom (UK) regarding the

The continued rise of paediatric home parenteral nutrition use: Implications for service and the improvement of longitudinal data collection Read More »

Chronic intestinal failure after Crohn disease: when to perform transplantation

AMA Surg. 2014 Oct;149(10):1060-6. doi: 10.1001/jamasurg.2014.1072. Undine A Gerlach, Georgios Vrakas, Srikanth Reddy, Daniel C Baumgart, Peter Neuhaus, Peter J Friend, Andreas Pascher, Anil VaidyaPMID: 25162284 DOI: 10.1001/jamasurg.2014.1072 Abstract Importance: Because of the severity of disease and additional surgery, Crohn disease (CD) may result in intestinal failure (IF) and dependency on home parenteral nutrition (HPN). Defining the indication and timing for intestinal transplantation (ITx) is

Chronic intestinal failure after Crohn disease: when to perform transplantation Read More »

S3-Guideline of the German Society for Nutritional Medicine (DGEM) in Cooperation with the GESKES, the AKE and the DGVS

Lamprecht G et al. S3-Leitlinie der Deutschen… Aktuel Ernahrungsmed 2014; 39: e57–e71 Andrew R Barclay, Paul Henderson, Henry Gowen, John Puntis; BIFS collaborators G. Lamprecht, U.-F. Pape, M. Witte, A. Pascher, und das DGEM Steering CommitteeISSN: 0341-0501 DOI:10.1055/s-0034-1369922 Abstract Introduction: Enteral and parenteral nutrition are the cornerstone for the therapy of short bowel syndrome and intestinal failure. The underlying anatomic

S3-Guideline of the German Society for Nutritional Medicine (DGEM) in Cooperation with the GESKES, the AKE and the DGVS Read More »

Das Kurzdarmsyndrom in Deutschland

von Websky MW, Liermann U, Buchholz BM, et al.: Das Kurzdarmsyndrom in Deutschland. Der Chir 2014; 85: 433–9. PMID: 24248157 DOI: 10.1007/s00104-013-2605-x Abstract Objective: As data about prevalence and standard of care in short bowel syndrome (SBS) are not available for Germany, this study estimated the prevalence and assessed the medical infrastructure to potentially improve care of SBS

Das Kurzdarmsyndrom in Deutschland Read More »

Chronic intestinal failure in children

Review: Dtsch Arztebl Int. 2012 Jun;109(22-23):409-15. doi: 10.3238/arztebl.2012.0409. Epub 2012 Jun 4. Michael B Krawinkel, Dietmar Scholz, Andreas Busch, Martina Kohl, Lukas M Wessel, Klaus-Peter ZimmerPMID: 22778793 DOI:10.3238/arztebl.2012.0409 Abstract Background: Chronic intestinal failure (CIF) in childhood is caused by congenital malformations and inflammatory diseases of the gut. Its reported prevalence is 13.7 per million population. Long-term home parenteral nutrition has dramatically improved the life expectancy

Chronic intestinal failure in children Read More »

Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model

Journal of Pediatric Gastroenterology and Nutrition 44(2):p 237-244, February 2007. Martina Kohl, Thilo Wedel, Andreas Entenmann, Julia Stuttmann, Meike Bendiks, Steffan Loff, Stefan Köster, Stefan Ortfeld, Inge BosDOI: 10.1097/01.mpg.0000252193.99331.03 Abstract OBJECTIVES: Long-term total parenteral nutrition (TPN) in children is often complicated by the development of cholestasis, liver fibrosis, and liver failure. High doses of intravenous lipids may be

Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model Read More »

Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates.

Wales PW, de Silva N, Kim J, Lecce L, To T, Moore A: Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates. J Pediatr Surg 2004; 39: 690–5. PMID: 15137001 DOI: 10.1016/j.jpedsurg.2004.01.036 Abstract Background: Congenital or acquired neonatal short bowel syndrome (SBS) carries significant morbidity and mortality rates. No accurate population estimates of incidence and mortality

Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates. Read More »

Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome.

Messing B, Crenn P, Beau P, Boutron-Ruault MC, Rambaud JC, Matuchansky C: Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome. Gastroenterology 1999; 117: 1043–50. PMID: 10535866 DOI: 10.1016/s0016-5085(99)70388-4 Abstract Background & aims: The short bowel syndrome (SBS) may be associated with either transient or permanent intestinal failure, presently treated by parenteral nutrition

Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome. Read More »

Nach oben scrollen
WordPress Cookie Plugin von Real Cookie Banner